A positive-selection function for microRNA: an adaptor hypothesis revisited.
نویسنده
چکیده
A hypothesis for coding different combinations of mRNA segments by a novel postulated function of microRNAs (miRNA) is presented. In this hypothesis, miRNA act as both coding adaptors and ligating enzymes. This hypothesis postulates an enzyme-substrate intermediate comprising a RNA triplex structure consisting of a miRNA adaptor and two mRNA configured as two turns of an A-form RNA helix. Postulating the existence of differentially expressed sets of adaptors (codes) may explain biological functions such as imprinting, differentiation, immunological escape and immunological tolerance, inter alia.
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ورودعنوان ژورنال:
- Reproductive biomedicine online
دوره 12 3 شماره
صفحات -
تاریخ انتشار 2006